 | | Autism Spectrum Screening Checklist (ASSC): The Development of a Scale to Identify High-Risk Individuals within the Children’s Mental Health System | Autism Spectrum Screening Checklist (ASSC): The Development of a Scale to Identify High-Risk Individuals within the Children’s Mental Health System
Autism Spectrum Screening Checklist (ASSC): The Development of a Scale to Identify High-Risk Individuals within the Children’s Mental Health System
Overview Autism Spectrum Disorder (ASD) is a complex childhood onset neurodevelopmental disorder that has become the fastest growing developmental disability. Due to the increased demand for diagnostic assessments and subsequent increased wait times, standardized screening as part of regular clinical practice is needed. More specifically there is an important need for the development of a more streamlined screening tool within an existing assessment system to identify those at greatest risk of having ASD. The ASSC scale provides an initial screen to help identify children and youth at heightened risk for autism within larger populations being assessed as part of routine practice. The main goal for the development and implementation of the ASSC scale is to harness the power of the existing interRAl assessment system to provide a more efficient, effective screening and referral process. This will ultimately help improve patient outcomes through needs-based care.
Journal Frontiers in Psychiatry Volume 12 | 3 | | R495.00 |  |
| | Learning Disabilities Elevate Children’s Risk for Behavioral-Emotional Problems | Learning Disabilities Elevate Children’s Risk for Behavioral-Emotional Problems
Learning Disabilities Elevate Children’s Risk for Behavioral-Emotional Problems
Overview
Our purpose was to study the frequency of behavioural-emotional problems among children identified with a learning disability (LD).
The study analysed the effect of the severity of LD and gender on the number of behavioural-emotional symptoms reported by teachers and parents. Alarmingly high percentages of children, irrespective of LD type, demonstrated behavioural-emotional problems: more than 37% in Affective, Anxiety, and Attention- Deficit/Hyperactivity Disorder (ADHD) problems. Contextual variation was large, as more problems were reported by teachers than by mothers. The unique effects of gender and LD type were rare, but the results raised concern for those with MD-only, especially boys. The results underscore the need to draw attention to the importance of assessing children with LD for behavioural-emotional problems and emphasize the importance of teachers’ awareness of behavioural-emotional problems among students with LD and cooperation among child, teacher, and parents in assessment and support planning.
Journal: Journal of learning Disabilities 2022 Volume 55 Issue 6
| 3 | | R480.00 | |
| | Relationship between chronic disease and depression: the mediating effect of pain | Relationship between chronic disease and depression: the mediating effect of pain
Relationship between chronic disease and depression: the mediating effect of pain
Overview The incidence of depression was high in people who were female, less educated, unmarried, living in rural areas, and working. Chronic diseases have a high incidence in China and may cause pain and depression. However, the association of chronic diseases with pain and the incidence of depression has not been comprehensively investigated.
The study population was obtained from the 2015 China Health and Retirement Longitudinal Study (CHARLS). The main outcome was the incidence of depression. The main independent variable was chronic disease (no chronic disease, one chronic disease, and two or more chronic diseases). The mediators were the degree of pain (no pain, mild pain, and moderate to severe pain) and whether measures were taken to relieve pain (measures taken and no measures taken). In conclusion the degree of pain had a partial mediating effect on chronic disease and depression. Pain relief measures should be considered when treating patients with depression.
| 3 | | R485.00 | |
| | Patients with Multiple Sclerosis in Psychotherapy: Processes of Meaning Making and Self Transformation | Patients with Multiple Sclerosis in Psychotherapy: Processes of Meaning Making and Self Transformation
Patients with Multiple Sclerosis in Psychotherapy: Processes of Meaning Making and Self Transformation
MS is a central nervous system disease which is characterised by demyelination, inflammation and neurodegeneration. There are about 2.2 million cases of MS worldwide.
The progression of the illness exhibits significant individual variation ranging from vision problems, fatigue, spasticity and pain to cognitive dysfunction and mood disorders
Recent empirical literature on autoimmune diseases has focused extensively on the implementation and evaluation of psychosocial interventions. Psychotherapy and counselling processes for multiple sclerosis (MS) have gained special attention given the cognitive and behavioural dimensions of the symptoms as well as their unpredictable course. The current study aims to gain a deeper understanding of the meaning making processes for persons with MS (PwMS) who are in psychotherapy treatment.
| 3 | | R485.00 | |
| | Acceptability and deliverability of an auditory rhythmical cueing (ARC) training programme for use at home and outdoors to improve gait and physical activity post-stroke | Acceptability and deliverability of an auditory rhythmical cueing (ARC) training programme for use at home and outdoors to improve gait and physical activity post-stroke
Acceptability and deliverability of an auditory rhythmical cueing (ARC) training programme for use at home and outdoors to improve gait and physical activity post-stroke
Overview Although laboratory studies demonstrate that training programmes using auditory rhythmical cueing (ARC) may improve gait post-stroke, few studies have evaluated this intervention in the home and outdoors where deployment may be more appropriate. This manuscript reports stakeholder refinement of an ARC gait and balance training programme for use at home and outdoors, and a study which assessed acceptability and deliverability of this programme. Programme design and content were refined during stakeholder workshops involving physiotherapists and stroke survivors. A two-group acceptability and deliverability study was then undertaken. It was concluded that an ARC gait and balance training programme refined by key stakeholders was feasible to deliver and acceptable to participants and providers.
Archives of Physiotherapy Vol. 12, Issue 1 | 3 | | R485.00 | |
| | A 20-Year Review of Biomechanical Experimental Studies on Spine Implants used for Percutaneous Surgical Repair of Vertebral Compression Fractures | A 20-Year Review of Biomechanical Experimental Studies on Spine Implants used for Percutaneous Surgical Repair of Vertebral Compression Fractures
A 20-Year Review of Biomechanical Experimental Studies on Spine Implants used for Percutaneous Surgical Repair of Vertebral Compression Fractures
A vertebral compression fracture (VCF) is an injury to a vertebra of the spine affecting the cortical walls and/or middle cancellous section. The most common risk factor for a VCF is osteoporosis, thus predisposing the elderly and postmenopausal women to this injury.
This article reviews over 20 years of scientific literature that has experimentally evaluated the biomechanics of percutaneous VCF repair methods. Specifically, this article describes the basic operating principles of the repair methods, the study protocols used to experimentally assess their biomechanical performance, and the actual biomechanical data measured, as well as giving several recommendations for future research directions.
| 3 | | R465.00 | |
| | Motion of lumbar endplate in degenerative lumbar scoliosis with different cobb angle in vivo: Reflecting the biomechanics of the lumbar disc | Motion of lumbar endplate in degenerative lumbar scoliosis with different cobb angle in vivo: Reflecting the biomechanics of the lumbar disc
Motion of lumbar endplate in degenerative lumbar scoliosis with different cobb angle in vivo: Reflecting the biomechanics of the lumbar disc
Degenerative lumbar scoliosis (DLS) was defined as a coronal Cobb angle greater than 10°. DLS is a de novo scoliosis with no previous history and is mainly related to age with an incidence of up to 60%. DLS can cause severe symptoms, such as low back pain, radiculopathy, and neurogenic claudication. The pathogenesis of DLS is both complex and controversial. Intervertebral disc degeneration (DD) has also been implicated in the development of DLS.
This study explored the ROM of the lumbar vertebral endplate in vivo to reflect disc deformation using a dual fluoroscopic imaging system. It was reported that the repeatability of the method in reproducing in vivo human spine 6 degree of freedom. Intervertebral DD is believed to have a detrimental effect on the ROM of the spinal segments in degenerative scoliosis.
The study also aimed to investigate the relationship between DD and the ROM of the lumbar vertebral endplates in patients with DLS. We hypothesized that the ROM of the lumbar endplate would be different in DLS patients with different Cobb angles. DD can increase the ROM of the lumbar vertebral endplate in patients with DLS. | 3 | | R425.00 | |
| | Nerve and Arterial Supply Pattern of the Popliteus Muscle and Clinical Implications | Nerve and Arterial Supply Pattern of the Popliteus Muscle and Clinical Implications
Nerve and Arterial Supply Pattern of the Popliteus Muscle and Clinical Implications
The popliteus muscle (PM) is a small muscle that acts as a major posterolateral stabilizer of the knee joint, rotating the tibia medially under the femur under non-weightbearing conditions. As the PM acts as an important factor in the movement and injury of the knee joint, anatomical studies have been conducted with a focus on the femoral attachment of the muscle.
Muscular spasticity is common in upper motor neuron syndrome. Injection treatment is applied as PM spasticity has been confirmed in many patients with in-toeing. One of the treatment methods, botulinum toxin, is known to have a long-lasting effect when injected into a site where the neuromuscular junction is dense. It is also effective when injected near the motor entry point where the nerve enters the muscle belly. Thus, a suitable injection site is thought to be the tibial region because the muscle belly is the upper portion on the tibial area on the posterior aspect. In this study, we speculated about the injection site of the PM based on the above reasoning. An alternative method is the accurate palpation of the PM, which is necessary for posture correction therapy.
The aim of this study was to investigate the nerve and artery supply and the tibial attachment of the popliteus muscle using anatomical methods.
| 3 | | R485.00 | |
| | The Relationship Between Additional Heads of the Quadriceps Femoris, the Vasti Muscles, and the Patellar Ligament | The Relationship Between Additional Heads of the Quadriceps Femoris, the Vasti Muscles, and the Patellar Ligament
The Relationship Between Additional Heads of the Quadriceps Femoris, the Vasti Muscles, and the Patellar Ligament
Overview
The quadriceps femoris consists of four muscles: the rectus femoris, vastus medialis, vastus intermedius, and vastus lateralis. However, the effect of additional quadriceps femoris heads on the vasti muscles and patellar ligaments is unknown. The quadriceps femoris muscle (QF) is important in locomotion; the rectus femoris (RF) swings the leg forward when a step is taken. During walking or running, quadriceps muscles such as the vastus medialis (VM) stabilize the patella and knee joint. The QF is important in sport owing to its potential for injury, which can be painful and debilitating.
The aims of the present study are to determine the relationship between additional quadriceps femoris heads and the vasti muscles and patellar ligaments and to review the morphology of the vastus lateralis, vastus medialis, and vastus intermedius.
Journal
Hindawi BioMed Research International
| 3 | | R465.00 | |
| | Five-Minute Cognitive Test as A New Quick Screning of Cognitive Impairment in the Elderly | Five-Minute Cognitive Test as A New Quick Screning of Cognitive Impairment in the Elderly
Five-Minute Cognitive Test as A New Quick Screning of Cognitive Impairment in the Elderly
Overview
As old population is dramatically growing, the detection of early cognitive deficit will become increasingly crucial. Effective cognitive screening test with quick and convenient merits will ensure recognition of early cognitive deficit and timely intervention. This study aims to develop a new evaluation method for quickly and conveniently screening cognitive impairment in the elderly.
The five-minute cognitive test (FCT) was designed to capture deficits in five domains of cognitive abilities, including episodic memory, language fluency, time orientation, visuospatial function, and executive function. Subsequently, FCT efficiencies in differentiating normally cognitive ability from cognitive impairment were explored and compared with that of the Mini-Mental Status Evaluation (MMSE). Equipercentile equating method was utilized to create a crosswalk between scores of the FCT and MMSE. Further, the association of scores of the FCT and MMSE with hippocampal volumes was investigated.
Many screening tools are currently available, but no tools meet the four important requirements for widespread use in clinical practice or large-scale epidemiological studies — that is, capture a clinically acceptable range of cognitive domains, take short time to administrate (around 5 minutes), have high accuracy for detecting cognitive impairment, and incorporate visual recall, which is the earliest deficits in Alzheimer’s disease (AD) patients. The FCT is a novel, reliable, and valid cognitive screening test for the detection of dementia at early stages.
Journal
JKL International LLC Aging and Disease Volume 10, Number 6 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844584/pdf/ad-10-6-1258.pdf | 3 | | R425.00 | |
| | Amygdala pathology in amyotrophic lateral sclerosis and primary lateral Sclerosis | Amygdala pathology in amyotrophic lateral sclerosis and primary lateral Sclerosis
Amygdala pathology in amyotrophic lateral sclerosis and primary lateral Sclerosis
Overview Temporal lobe studies in motor neuron disease overwhelmingly focus on white matter alterations and cortical grey matter atrophy. Reports on amygdala involvement are conflicting and the amygdala is typically evaluated as single structure despite consisting of several functionally and cytologically distinct nuclei. A prospective, single-centre, neuroimaging study was undertaken to comprehensively characterise amygdala pathology in 100 genetically stratified ALS patients, 33 patients with PLS and 117 healthy controls. Our findings highlight that the amygdala is affected in ALS and our study demonstrates the selective involvement of specific nuclei as opposed to global atrophy. The genotype-specific patterns of amygdala involvement identified by this study are consistent with the growing literature of extra-motor clinical features. Mesial temporal lobe pathology in ALS is not limited to hippocampal pathology but, as a key hub of the limbic system, the amygdala is also affected in ALS.
Authors Rangariroyashe H. Chipikaa, Foteini Christidia, Eoin Finegan, Stacey Li Hi Shing, Mary Clare McKenna, Kai Ming Chang, Efstratios Karavasilis, Mark A. Doherty, Jennifer C. Hengeveld, Alice Vajda, Niall Pender, Siobhan Hutchinson, Colette Donaghy, Russell L. McLaughlin, Orla Hardiman, Peter Bede
| 3 | | R380.00 | |
| | Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study | Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study
Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study
Overview The spectrum of neurological and psychiatric complications associated with paediatric SARS-CoV-2 infection is poorly understood. This study aimed to analyse the range and prevalence of these complications in hospitalised children and adolescents. A national cohort study was conducted in the UK using an online network of secure rapid-response notification portals established by the CoroNerve study group. Patients were excluded if they did not have a neurological consultation or neurological investigations or both or did not meet the definition for confirmed SARS-CoV-2 infection (a positive PCR or respiratory or spinal fluid samples, serology for anti-SARS-CoV-2 IgG, or both). Individuals were classified as having either a primary neurological disorder associated with COVID-19 (COVID-19 neurology group) or PIMS-TS with neurological features (PIMS-TS neurology group). The denominator of all hospitalised children and adolescents with COVID-19 was collated from National Health Service England data. This study identified key differences between those with a primary neurological disorder versus those with PIMS-TS. Compared with patients with a primary neurological disorder, more patients with PIMS-TS needed intensive care, but outcomes were similar overall.
Authors Stephen T J Ray et al
Journal The Lancet Child & Adolescent Health | 3 | | R410.00 | |
| | HIV and Aids | HIV and Aids
Overview
HIV disease is caused by infection with HIV-1 or HIV-2, which are retroviruses in the Retroviridae family, Lentivirus genus. Human immunodeficiency virus (HIV) is a blood-borne virus typically transmitted via sexual intercourse, shared intravenous drug paraphernalia, and mother-to-child transmission (MTCT), which can occur during the birth process or during breastfeeding. The patient with HIV may present with signs and symptoms of any of the stages of HIV infection. No physical findings are specific to HIV infection; the physical findings are those of the presenting infection or illness. Examples of manifestations include acute seroconversion manifests as a flulike illness, consisting of fever, malaise, generalized rash, generalized lymphadenopathy is common and may be a presenting symptom. This course covers the screening, diagnosis, medication and management of Aids.
Author: Sharespike | 3 | | R425.00 | |
| | Pain Management through Neurocognitive Therapeutic Exercises in Hypermobile Ehlers–Danlos Syndrome Patients with Chronic Low Back Pain | Pain Management through Neurocognitive Therapeutic Exercises in Hypermobile Ehlers–Danlos Syndrome Patients with Chronic Low Back Pain
Pain Management through Neurocognitive Therapeutic Exercises in Hypermobile Ehlers–Danlos Syndrome Patients with Chronic Low Back Pain
Overview The hypermobile type of Ehlers–Danlos syndrome (hEDS) is likely the most common hereditary disorder of connective tissue mainly characterized by joint hypermobility. Patients with hEDS suffer joint pain, in particular low back pain, commonly resistant to drug therapy. The aim of this research was to evaluate a neurocognitive rehabilitation approach based not only on the motion and function recovery but also on the pain management. In this nonrandomized clinical trial, eighteen hEDS patients (4 males and 14 females) with mean age 21 years (range 13-55) were recruited and evaluated before and after three months of rehabilitation treatment. The clinical results observed in this study seem to confirm the role of a specific neurocognitive rehabilitation program in the chronic pain management in the Ehlers–Danlos syndrome; the rehabilitation treatment should be tailored on patient problems and focused not only in the recovery of movement but also on pain perception.
Authors Claudia Celletti, Teresa Paolucci , Loredana Maggi, Giordana Volpi, Mariangela Billi, Roberta Mollica,and Filippo Camerota
Journal Hindawi BioMed Research International | 3 | | R435.00 | |
| | Ischemic Stroke Part 2 | Ischemic Stroke Part 2
Overview
Ischemic stroke is characterized by the sudden loss of blood circulation to an area of the brain, resulting in a corresponding loss of neurologic function. Acute ischemic stroke is caused by thrombotic or embolic occlusion of a cerebral artery and is more common than haemorrhagic stroke.
We should consider stroke in any patient presenting with acute neurologic deficit or any alteration in level of consciousness. Although symptoms can occur alone, they are more likely to occur in combination. No historical feature distinguishes ischemic from haemorrhagic stroke, although nausea, vomiting, headache, and sudden change in level of consciousness are more common in haemorrhagic strokes. In younger patients, a history of recent trauma, coagulopathies, illicit drug use (especially cocaine), migraines, or use of oral contraceptives should be elicited.
Emergent brain imaging is essential for evaluation of acute ischemic stroke. Noncontrast computed tomography (CT) scanning is the most commonly used form of neuroimaging in the acute evaluation of patients with apparent acute stroke.
Involvement of a physician with a special interest and training in stroke is ideal. Stroke care units with specially trained nursing and allied healthcare personnel have clearly been shown to improve outcomes.
Author Sharespike
| 3 | | R410.00 | |
| | Ischemic Stroke Part 1 | Ischemic Stroke Part 1
Overview
Ischemic stroke is characterized by the sudden loss of blood circulation to an area of the brain, resulting in a corresponding loss of neurologic function. Acute ischemic stroke is caused by thrombotic or embolic occlusion of a cerebral artery and is more common than haemorrhagic stroke.
We should consider stroke in any patient presenting with acute neurologic deficit or any alteration in level of consciousness. Although symptoms can occur alone, they are more likely to occur in combination. No historical feature distinguishes ischemic from haemorrhagic stroke, although nausea, vomiting, headache, and sudden change in level of consciousness are more common in haemorrhagic strokes. In younger patients, a history of recent trauma, coagulopathies, illicit drug use (especially cocaine), migraines, or use of oral contraceptives should be elicited.
Emergent brain imaging is essential for evaluation of acute ischemic stroke. Noncontrast computed tomography (CT) scanning is the most commonly used form of neuroimaging in the acute evaluation of patients with apparent acute stroke.
Involvement of a physician with a special interest and training in stroke is ideal. Stroke care units with specially trained nursing and allied healthcare personnel have clearly been shown to improve outcomes.
Author Sharespike
| 3 | | R410.00 | |
| | The Effects of a Recollection-Based Occupational Therapy Program of Alzheimer’s Disease: A Randomized Controlled Trial | The Effects of a Recollection-Based Occupational Therapy Program of Alzheimer’s Disease: A Randomized Controlled Trial
The Effects of a Recollection-Based Occupational Therapy Program of Alzheimer’s Disease: A Randomized Controlled Trial
Overview:
Considering the high socio-economic costs related to the increasing number of dementia patients and their poor quality of life and that of their families, it is important to identify the condition early on and provide an appropriate intervention. This study organized a recollection-based occupational therapy program: a nonpharmacological intervention consisting of five categories of activities (physical, horticultural, musical, art, and instrumental activity of daily living; IADL) and applied it to those having a mild stage of Alzheimer’s disease. The experimental group participated in a total of 24 sessions––five times per week for one hour per session––while the control group took part in regular activities offered by the existing facilities. The experimental group presented improved cognitive functions, reduced depression, and enhanced quality of life; the two groups showed a statistically significant difference in every category. This study is meaningful in that it made a cognitive stimulation program concerning five different categories, implemented it for people suffering mild dementia, and confirmed positive outcomes. If a systemic version of the program is offered in dementia care facilities, it is expected to make a considerable contribution to the care of dementia patients.
Acknowledgements: Authors: DeokJu Kim
Journal: Occupational Therapy International | 3 | | R435.00 | |
| | Preretinal hemorrhage following chiropractor neck manipulation | Preretinal hemorrhage following chiropractor neck manipulation
Preretinal hemorrhage following chiropractor neck manipulation
Overview The purpose of this study is to report a case of a new complication following complementary and alternative medicine chiropractor neck manipulation with multiple preretinal haemorrhages. A 59-year-old Caucasian female presented with the acute, painless constant appearance of 3 spots in her vision immediately after a chiropractor performed cervical spinal manipulation using the high-velocity, low-amplitude technique. Examination multiple unilateral preretinal haemorrhages with no retinal tears. The preretinal haemorrhages were self-limited and resolved by 2 months later. In conclusion, the Chiropractor neck manipulation has previously been reported leading to complications related to the carotid artery and arterial plaques. This presents the ?rst case of multiple unilateral preretinal haemorrhages immediately following chiropractic neck manipulation. This suggests that chiropractor spinal adjustment cannot only a?ect the carotid artery, but also could lead to preretinal haemorrhages.
Acknowledgement Authors Yannis M. Paulusa and Nicholas Belillb Journal American Journal of Ophthalmology
| 3 | | R435.00 | |
| | Locked-In Syndrome Following Cervical Manipulation by a Chiropractor: A Case Report | Locked-In Syndrome Following Cervical Manipulation by a Chiropractor: A Case Report
Locked-In Syndrome Following Cervical Manipulation by a Chiropractor: A Case Report
Overview Vertebrobasilar occlusion poses difficult diagnostic issues and even when properly diagnosed has a poor prognosis. Newer studies highlight a better outcome when thrombectomy was carried out between six and twenty-four hours after an initial diagnosis of stroke. This paper reports a case where a patient suffered a vertebrobasilar stroke secondary to a traumatic bilateral vertebral arteries dissection was treated with late thrombectomy. A 34-year-old woman was manipulated on the cervical spinal column by a chiropractor. Following three weeks of cervical pain, she presented with severe aphasia and quadriplegia (NIHSS = 28). An MRI scan indicated ischemia of the vertebrobasilar system. Thirty-one hours after the onset of these symptoms, a thrombectomy was performed. After one month, the patient could move her head and the proximal part of her limbs but remained confined to bed (NIHSS = 13). In conclusion, the current case illustrates the benefit of late mechanical thrombectomy for a posterior cerebral circulation infarct. Although there was a delay in treatment, partial recovery ensued. Acknowledgments
Authors Guillaume Giordano Orsini, Giorgios-Emmanouil Metaxas, Vincent Legros Journal
The Journal of Critical Care
| 3 | | R410.00 | |
| | Convulsions and Seizures | Convulsions and Seizures
Overview
Emergency services attend patients who are having a seizure on almost a daily basis. Consequently, they should understand the disease processes related to seizures and be confident in their prehospital management. In general, with the exception of a patient in Status Epilepticus, seizure management should be relatively straight forward.
So, what is a seizure and what causes it? Basically, a seizure is any unusually excessive neuronal firing from the brain which manifests as changes in a patient’s motor/sensory control, sensory perception, behaviour and autonomic function.
At a chemical level a seizure occurs when there is a sudden biochemical imbalance between the excitatory neurotransmitters and inhibitory neurotransmitters. The primary excitatory neurotransmitter found in the human central nervous system is called N-Methyl D Aspartate (NMDA); whereas the primary inhibitory neurotransmitter is called gamma-amino butyric acid (GABA). When there is an imbalance between these chemical mediators repeated firing and excitations of the neuronal cells occur.
Depending on the area of the brain in which this occurs, the seizure will manifest as a focal seizure, sensory change, behaviour disturbance, or complete tonic and clonic muscular activity. This course addresses important aspects relating to convulsions and seizures
| 3 | | R460.00 | |
| | Predisposing factors and radiological features in patients with internal carotid artery dissection or vertebral artery dissection | Predisposing factors and radiological features in patients with internal carotid artery dissection or vertebral artery dissection
Predisposing factors and radiological features in patients with internal carotid artery dissection or vertebral artery dissection
Overview
Cranio-cervical artery dissection (CAD) refers to a tear in the artery lining, resulting in an intramural hematoma toward the intima or the adventitia of the internal carotid artery or vertebral artery. CAD is an important cause of ischemic stroke in young and middle-aged individuals. However, very few studies have compared the differential features between internal carotid artery dissection (ICAD) and vertebral artery dissection (VAD), including both cervical and intracranial artery dissections. CAD can affect the cranial or cervical portion of the internal carotid artery or vertebral artery. The predisposing factors, clinical presentation, radiological imaging, and outcome may differ between ICAD and VAD.
We conducted a study to investigate the predisposing factors and radiological features in patients with ICAD or VAD. It was found that the distribution of cervical and intracranial artery dissections was different between ICAD and VAD. The frequencies of radiological features such as double lumen, intimal flap, and dissecting aneurysms also differed in patients with ICAD and VAD.
Authors Yongjun Wu, Hongbin Chen, Shihui Xing, Shuangquan Tan, Xinran Chen, Yan Tan, Jinsheng Zeng and Jian Zhang
| 3 | | R390.00 | |
| | Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. | Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides.
Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides.
Overview The aim of the study was to evaluate the use of specific collagen peptides in reducing pain in athletes with functional knee problems during sport. The primary outcome of the study was in change in pain intensity during activity, which was evaluated by the participants and the attending physicians using a visual analogue scale. As secondary endpoints, pain intensity under resting conditions, the range of motion of the knee joint, and the use of additional therapeutic options were assessed. Due to the high joint mobility at baseline, no significant changes of this parameter could be detected. The use of additional treatment options was significantly reduced after BCP intake. The study demonstrated that the supplementation of specific collagen peptides in young adults with functional knee problems led to a statistically significant improvement of activity related joint pain.
Authors: Denise Zdzieblik, Steffen Oesser, Albert Gollhofer and Daniel König
| 3 | | R420.00 | |
| | The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function? | The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function?
The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function?
Overview: Hearing loss is a modifiable risk factor for dementia in older adults. Whether hearing aid use can delay the onset of cognitive decline is unknown. Participants in this study (aged 62–82 years) were assessed before and 18 months after hearing aid fitting on hearing, cognitive function, speech perception, quality of life, physical activity, loneliness, isolation, mood, and medical health.
At baseline, multiple linear regression showed hearing loss and age predicted significantly poorer executive function performance, while tertiary education predicted significantly higher executive function and visual learning performance. At 18 months after hearing aid fitting, speech perception in quiet, self-reported listening disability and quality of life had significantly improved. Group mean scores across the cognitive test battery showed no significant decline, and executive function significantly improved.
Authors: Julia Sarant, David Harris, Peter Busby, Paul Maru, Adrian Schembri, Ulrike Lemke and Stefan Launer
Article: J. Clin. Med. 2020
| 3 | | R380.00 | |
| | Extracorporeal Shock Wave Therapy for Achilles Tendinopathy | Extracorporeal Shock Wave Therapy for Achilles Tendinopathy
Extracorporeal Shock Wave Therapy for Achilles Tendinopathy
Overview
Achilles tendinopathy is confirmed by a clinical symptom triad of pain, swelling, and limited function. Achilles tendon injuries are classified by the anatomical area into non-insertional and insertional. The major symptom of non-insertional tendinopathy is pain located 2 to 6 cm proximal to the insertion of the tendon into the calcaneus. Patients suffering from insertional pathology usually present with lesions in the distal portion of the structure, i.e., posterosuperior calcaneal protuberance. Extracorporeal shock wave therapy (ESWT) is among the conservative treatments for Achilles tendinopathy. Unfortunately, no optimal application parameters have been determined that would ensure ESWT effectiveness in this condition. +e aim of the paper is to use research reports on ESWT in patients with Achilles tendinopathy to help practising physiotherapists establish the most effective intervention parameters. The two modalities of shock wave therapy used for Achilles tendinopathy are focused shock waves and radial shock waves. The literature contains reports presenting mainly beneficial effects of ESWT in patients with Achilles tendinopathy.
Authors Magdalena Stania, Grzegorz Juras, Daria Chmielewska, Anna Polak, Cezary Kucio, and Piotr Król
Journal BioMed Research International / 2019 / Article | 3 | | R425.00 | |
| | Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019 | Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019
Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019
Overview
The world’s population is ageing and the number of people living with non-communicable diseases and the consequences of injuries is increasing.The current demographic and health shifts are contributing to a rapid increase in the number of people experiencing disability or declines in functioning for substantially larger periods of their lives. These trends should urge health policy planners to prioritise rehabilitation services for several reasons.
Rehabilitation has often been a disability-specific service needed by only few of the population. Despite its individual and societal benefits, rehabilitation has not been prioritised in countries and is under-resourced. We present global, regional, and country data for the number of people who would benefit from rehabilitation at least once during their disabling illness or injury.
To the authors knowledge, this is the first study to produce a global estimate of the need for rehabilitation services and to show that at least one in every three people in the world needs rehabilitation at some point in the course of their illness or injury. This number counters the common view of rehabilitation as a service required by only few people. They argue that rehabilitation needs to be brought close to communities as an integral part of primary health care to reach more people in need.
Authors Alarcos Cieza, Kate Causey, Kaloyan Kamenov, Sarah Wulf Hanson, Somnath Chatterji, Theo Vos
Journal The Lancet Journal
| 3 | | R410.00 | |
| | Prevalence of Muscular Skeletal Disorders among Qualified Dental Assistants | Prevalence of Muscular Skeletal Disorders among Qualified Dental Assistants
Prevalence of Muscular Skeletal Disorders among Qualified Dental Assistants
Overview: The occupation of dental assistants (DAs) involves many health risks of the musculoskeletal system due to static and prolonged work, which can lead to musculoskeletal disorders (MSDs). The aim of the study was to investigate the prevalence of MSDs in DAs in Germany. For this purpose, an online questionnaire analyzed 406 (401 female participants and 5 male participants, 401w/5m) DAs. It was based on the Nordic Questionnaire (lifetime, 12-month, and seven-day MSDs’ prevalence separated into neck, shoulder, elbow, wrist, upper back, lower back, hip, knee, and ankle), and occupational and sociodemographic questions as well as questions about specific medical conditions. 98.5% of the participants reported complaints of at least one body region in their lives, 97.5% reported at least one complaint in the last 12 months and 86.9% armed at least one complaint in the last seven days. For lifetime, 12-month and seven-day prevalence, the neck was the region that was most affected followed by the shoulder, the upper back and the lower back.
The prevalence of musculoskeletal disorders among Dental Assistants was extremely high. The most affected area is the neck, followed by the shoulder, the lower back, and the upper back. It, therefore, seems necessary to devote more attention to ergonomics at the working practice of Dental Assistants as well in education and in dental work.
Authors: Daniela Ohlendorf, Yvonne Haas, Antonia Naser, Jasmin Haenel, Laura Maltry, Fabian Holzgreve, Christina Erbe, Werner Betz, Eileen M. Wanke, Dörthe Brüggmann, Albert Nienhaus and David A. Groneberg
Journal: Int. J. Environ. Res. Public Health 2020, 17, 3490;
| 3 | | R420.00 | |
| | Tuberculosis Part 1 | Tuberculosis Part 1
Overview Tuberculosis (TB) (see the image below), a multisystemic disease with myriad presentations and manifestations, is the most common cause of infectious disease–related mortality worldwide. Although TB rates are decreasing in the United States, the disease is becoming more common in many parts of the world. In addition, the prevalence of drug-resistant TB is increasing worldwide. Classic clinical features associated with active pulmonary TB in elderly individuals with TB may not display typical signs and symptoms. The absence of any significant physical findings does not exclude active TB. Classic symptoms are often absent in high-risk patients, particularly those who are immunocompromised or elderly. It is important to isolate patients with possible TB in a private room with negative pressure.
Acknowledgements Authors: Thomas E Herchline and Judith K Amorosa | 3 | | R420.00 | |
| | Clinical Practice Guidelines: Seizures | Clinical Practice Guidelines: Seizures
Clinical Practice Guidelines: Seizures
Overview
Paediatric and adult seizures are managed in essentially the same way, with the focus on identification, injury prevention, rapid termination and prevention of ongoing seizures; ongoing attention must be paid to reversal of the cause of the seizure. Important differences in children relate to febrile seizures (covered in section 3: Fever & Sepsis) and easily correctable causes such as hypoglycaemia. Acknowledgement
Journal: Clinical Practice Guidelines (July 2018) Publisher: Health Professions Council of South Africa | 3 | | R410.00 | |
| | Inference comprehension in text reading: Performance of individuals with right- versus left-hemisphere lesions and the influence of cognitive functions | Inference comprehension in text reading: Performance of individuals with right- versus left-hemisphere lesions and the influence of cognitive functions
Inference comprehension in text reading: Performance of individuals with right- versus left-hemisphere lesions and the influence of cognitive functions
Overview
Right-hemisphere lesions (RHL) may impair inference comprehension. However, comparative studies between left-hemisphere lesions (LHL) and RHL are rare, especially regarding reading comprehension. Moreover, further knowledge of the influence of cognition on inferential processing in this task is needed. The LHL and RHL groups presented difficulties in inferential comprehension in comparison with the CG. However, the RHL group presented lower scores than the LHL group on logical, pragmatic and other questions. A covariance analysis did not show any effect of lesion site within the hemispheres.
Attention and visuospatial abilities affected the scores of both the RHL and LHL groups, and only memory influenced the performance of the RHL group. Lesions in either hemisphere may cause difficulties in making inferences during reading. However, processing more complex inferences was more difficult for patients with RHL than for those with LHL, which suggests that the right hemisphere plays an important role in tasks with higher comprehension demands. Cognition influences inferential processing during reading in brain-injured subjects.
Acknowledgement
Authors Marcela Lima Silagi, Marcia Radanovic, Adriana Bastos Conforto, Lucia Iracema Zanotto Mendonca and Leticia Lessa Mansur
Journal PLoS ONE | 3 | | R410.00 | |
| | Functional Communication Profiles in Children with Cerebral Palsy in Relation to Gross Motor Function and Manual and Intellectual Ability | Functional Communication Profiles in Children with Cerebral Palsy in Relation to Gross Motor Function and Manual and Intellectual Ability
Functional Communication Profiles in Children with Cerebral Palsy in Relation to Gross Motor Function and Manual and Intellectual Ability
Overview
The aim of the present study was to investigate communication function using classification systems and its association with other functional profiles, including gross motor function, manual ability, intellectual functioning, and brain magnetic resonance imaging (MRI) characteristics in children with cerebral palsy (CP). Multiple logistic regression analysis indicated that manual ability and intellectual functioning were significantly related with VSS and CFCS function, whereas only intellectual functioning was significantly related with SLPG functioning in children with CP.
Communication function in children with a peri-ventricular white matter lesion (PVWL) varied widely. In the cases with a PVWL, poor functioning was more common on the SLPG, compared to the VSS and CFCS. Compared to the children with bilateral spastic CP, the children with dyskinetic CP had more severe gross motor impairment, although there were no statistical differences in communication function between groups. Very strong relationships were noted among three communication classification systems that are closely related with intellectual ability. Compared to gross motor function, manual ability seemed more closely related with communication function in these children.
Acknowledgement
Authors Ja Young Choi, Jieun Park, Yoon Seong Choi, Yu-ra Goh and Eun Sook Park
Journal Yonsei Medical Journal
| 3 | | R425.00 | |
| | Pediatric Minor Head Injury 2.0: Moving from Injury Exclusion to Risk Stratification - Emergency Medicine Clinics of North America | Pediatric Minor Head Injury 2.0: Moving from Injury Exclusion to Risk Stratification - Emergency Medicine Clinics of North America
Pediatric Minor Head Injury 2.0: Moving from Injury Exclusion to Risk Stratification - Emergency Medicine Clinics of North America
Overview
ED and primary care provider visits for pediatric minor BHT continue to increase. Considerable variability exists in clinician evaluation and management of this generally low- risk population. CDRs should be used to assist providers in identification of very low-risk individuals, eliminating the need for cranial CT scans. The use of periods of observation before imaging can also decrease scanning rates. Outcome data from past retrospective studies as well as prospective data accumulated during the derivation and validation of the PECARN head injury decision rules for children less than 2 years and 2 to 18 years of age can be used to further risk stratify children with minor BHT who are at intermediate or high risk for ciTBI into more discrete categories.
Incorporation of decision aids into practice can be useful for increasing caregiver knowledge and accuracy of risk perception and improve provider identification of patient or caregiver preferences. This can help to facilitate shared decision-making regarding imaging or observation. For children in whom imaging is performed and is normal or shows only isolated linear skull fractures, the rates of deterioration and neurosurgical intervention are rare and, therefore, hospital admission can likely be avoided.
Acknowledgement
Author James (Jim) L. Homme, MD
Journal Emergency Medicine Clinics of North America
| 3 | | R425.00 | |
| | Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer | Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer
Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer
Overview
Interventions to reduce the risk for cerebrovascular events (CVE; stroke and transient ischemic attack [TIA]) after radiotherapy (RT) for head and neck cancer (HNCA) are needed. We aimed to test whether incidental statin use at the time of RT is associated with a lower rate of CVEs after RT for HNCA.
From an institutional database we identified all consecutive subjects treated with neck RT from 2002 to 2012 for HNCA. Data collection and event adjudication was performed by blinded teams. The primary outcome was a composite of ischemic stroke and TIA. The secondary outcome was ischemic stroke. The association between statin use and events was determined using Cox proportional hazard models after adjustment for traditional and RT-specific risk factors.
Incidental statin use at the time of RT for HNCA is associated with a lower risk of stroke or TIA.
Acknowledgement
Authors
Daniel Addison, Patrick R. Lawler, Hamed Emami, Sumbal A. Janjua, Pedro V. Staziaki, Travis R. Hallett, Orla Hennessy, Hang Lee, Bálint Szilveszter, Michael Lu, Negar Mousavi, Matthew G. Nayor, Francesca N. Delling, Javier M. Romero, Lori J. Wirth, Annie W. Chan, Udo Hoffmann, Tomas G. Neilan
Journal Journal of Stroke Publisher Cross Mark | 3 | | R420.00 | |
| | Simultaneous Detection of Key Bacterial Pathogens Related to Pneumonia and Meningitis Using Multiplex PCR Coupled With Mass Spectrometry | Simultaneous Detection of Key Bacterial Pathogens Related to Pneumonia and Meningitis Using Multiplex PCR Coupled With Mass Spectrometry
Simultaneous Detection of Key Bacterial Pathogens Related to Pneumonia and Meningitis Using Multiplex PCR Coupled With Mass Spectrometry
Overview
Pneumonia and meningitis continue to present an enormous public health burden and pose a major threat to young children. Among the causative organisms of pneumonia and meningitis, bacteria are the most common causes of serious disease and deaths. It is challenging to accurately and rapidly identify these agents.
Using the BP-MS method, we could accurately identify the expected bacteria without cross-reactivity with other pathogens. For the 11 target bacterial pathogens, the analytical sensitivity of the BP-MS method was as low as 10 copies/reaction. To further evaluate the clinical effectiveness of this method, 204 nasopharyngeal swabs from hospitalized children with suspected pneumonia were tested using this method.
We used real-time PCR and nested PCR to confirm positive results, with identical results obtained for 81.4% (136/167) of the samples. The BP-MS method is a sensitive and specific molecular detection technique in a multiplex format and with high sample throughput. Therefore, it will be a powerful tool for pathogen screening and antibiotic selection at an early stage of disease.
Acknowledgements
Authors Chi Zhang, Leshan Xiu, Yan Xiao, Zhengde Xie, Lili Ren and Junping Peng
Journal Frontiers in Cellular and Infection Microbiology Volume 8
Publisher Cross Mark
| 3 | | R460.00 | |
| | Motor and Psychosocial Impact of Robot-assisted Gait Training in A Real-world Rehabilitation Setting: A pilot study | Motor and Psychosocial Impact of Robot-assisted Gait Training in A Real-world Rehabilitation Setting: A pilot study
Motor and Psychosocial Impact of Robot-assisted Gait Training in A Real-world Rehabilitation Setting: A pilot study
Overview
In the last decade robotic devices have been applied in rehabilitation to overcome walking disability in neurologic diseases with promising results. Robot assisted gait training (RAGT) using the Lokomat seems not only to improve gait parameters but also the perception of well-being. Data on the psychosocial patient-robot impact are limited, in particular in the real-world of RAGT, in the rehabilitation setting.
The primary aim of this pilot study was to evaluate the psychosocial impact of the Lokomat in an in-patient rehabilitation setting using the PIADS; secondary aims were to assess whether the psycho-social impact of RAGT is different between pathological subgroups and if the Lokomat influenced functional variables. Thirty-nine consecutive patients were assessed with the FIM before and after rehabilitation with Lokomat, and the PIADS was administered after the rehabilitative period with Lokomat. This pilot study indicates that Lokomat, in a real-world in-patient setting, may have a generalised approval, independent of disease, underlining the importance of the psycho-social framework for patients training with assistive robotic-devices.
Acknowledgement
Authors: Cira Fundarò, Anna Giardini, Roberto Maestri, Silvia Traversoni, Michelangelo Bartolo and Roberto Casale
Journal PLoS ONE
Publisher Cross Mark
| 3 | | R430.00 | |
| | Early Intervention for Children with Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research. | Early Intervention for Children with Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research.
Early Intervention for Children with Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research.
Overview
This article reviews current evidence for autism spectrum disorder (ASD) interventions for children aged <3 years, based on peer-reviewed articles published up to December 2013. Several groups have adapted treatments initially designed for older, preschool-aged children with ASD, integrating best practice in behavioural teaching methods into a developmental framework based on current scientific understanding of how infants and toddlers learn. The central role of parents has been emphasized and facilitating the generalization of skills beyond the familiar home setting. Our review identified several comprehensive and targeted treatment models with evidence of clear benefits. Although some trials were limited to 8- to 12-week outcome data, enhanced outcomes associated with some interventions were evaluated over periods as long as 2 years. Based on this review, recommendations are proposed for clinical practice and future research.
Acknowledgement:
Authors: Zwaigenbaum L, Bauman ML, Choueiri R, Kasari C, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins D, Wetherby A, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR
Journal: Pediatrics. Publisher: American Academy of Pediatrics
| 3 | | R465.00 | |
| | Assessing malpractice lawsuits for death or injuries due to amniotic fluid embolism | Assessing malpractice lawsuits for death or injuries due to amniotic fluid embolism
Assessing malpractice lawsuits for death or injuries due to amniotic fluid embolism
Assessing malpractice lawsuits for death or injuries due to amniotic fluid embolism
Overview
Amniotic fluid embolism (AFE) is a pregnancy complication known to be extremely hard to diagnose, since it manifests itself abruptly and with no warning signs, presenting an incidence rate of about 1 in 40000 deliveries, and maternal morbidity and mortality ranging from 20% to 60%. Despite medical research having been conducted on such a syndrome, diagnostic procedures and treatment methods have not yet been clarified enough.
Specific biochemical markers have been produced in research laboratories, but their clinical value results to be limited, given how rapid the pathological process moves forward. At the time being, no diagnosis is feasible which may effectively prevent the disease from occurring. Certainly, a multi-disciplinary approach might contribute to saving the lives of mother and infant, as well as ensuring better life standards.
It becomes essential to further scientific knowledge of the causes of maternal death. In such a way, it will be possible to improve the quality standards of care and avert many pregnancy-related deaths. It is well-known how age of the mother also plays a role in determining the likelihood of developing AFE.
Acknowledgements
Authors S. Zaami , E. Marinelli and G. Montanari Vergallo
Journal Clin Ter 2017 Volume 168 Issue 3
| 3 | | R455.00 | |
| | Postural Tremor and Ataxia Progression in Spino-cerebellar Ataxias | Postural Tremor and Ataxia Progression in Spino-cerebellar Ataxias
Postural Tremor and Ataxia Progression in Spino-cerebellar Ataxias
Postural Tremor and Ataxia Progression in Spino-cerebellar Ataxias
Overview
Postural tremor can sometimes occur in spino-cerebellar ataxias (SCAs). However, the prevalence and clinical characteristics of postural tremor in SCAs are poorly understood, and whether SCA patients with postural tremor have different ataxia progression is not known. Postural tremor could be a clinical feature of SCAs, and the presence of postural tremor could be associated with different rates of ataxia progression. Genetic interactions between ataxia genes might influence the brain circuitry and thus affect the clinical presentation of postural tremor.
In conclusion, our study indicates that postural tremor could be present in the four most common SCAs and that SCA patients with postural tremor might have a different rate of ataxia progression. Genetic interactions between ataxia genes might influence the brain circuitry involved and thus affect the clinical presentation of postural tremor.
Acknowledgement
Author
Shi-Rui Gan, Jie Wang, Karla P. Figuero, Stefan M. Pulst, Darya Tomishon, Danielle Lee, Susan Perlman, George Wilmot, Christopher M. Gomez, Jeremy Schmahmann, Henry Paaulson, Vikram G. Shakkottai, Sarah H. Ying, Theresa Zesiewicz, Khalaf Bushara, Michael D. Geschwind, Guangbin Xia, S. H. Subramony Tetsuo Ashizawa and Sheng-Han Kuo.
Journal Tremor Other Hyperkinet Movement (NY) URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647398/pdf/tre-07-492-7522-1.pdf Disciplines: Neurology, Surgeons, Physicians
| 3 | | R465.00 | |
| | Effects of Aerobic Exercise on Brain Metabolism and Grey Matter Volume in Older Adults: Results of the Randomised Controlled SMART Trial | Effects of Aerobic Exercise on Brain Metabolism and Grey Matter Volume in Older Adults: Results of the Randomised Controlled SMART Trial
Effects of Aerobic Exercise on Brain Metabolism and Grey Matter Volume in Older Adults: Results of the Randomised Controlled SMART Trial
Effects of Aerobic Exercise on Brain Metabolism and Grey Matter Volume in Older Adults: Results of the Randomised Controlled SMART Trial
Overview
There is mounting evidence that aerobic exercise has a positive effect on cognitive functions in older adults. The present study used magnetic resonance spectroscopy and quantitative MRI to systematically explore the effects of physical activity on human brain metabolism and grey matter (GM) volume in healthy aging. The main outcomes were the change in cerebral metabolism and its association to brain-derived neurotrophic factor (BDNF) levels as well as changes in GM volume. We found that cerebral choline concentrations remained stable after 12 weeks of aerobic exercise in the intervention group, whereas they increased in the waiting control group.
No effect of training was seen on cerebral N-acetylaspartate concentrations, nor on markers of neuronal energy reserve or BDNF levels. Further, we observed no change in cortical GM volume in response to aerobic exercise. The finding of stable choline concentrations in the intervention group over the 3 month period might indicate a neuro-protective effect of aerobic exercise. Choline might constitute a valid marker for an effect of aerobic exercise on cerebral metabolism in healthy aging.
Acknowledgement
S Matura, J Fleckenstein, R Deichmann, T Engeroff, E Füzéki, E Hattingen, R Hellweg, B Lienerth, U Pilatus, S Schwarz, VA Tesky, L Vogt, W Banzer and J Pantel.
Journal Nature Translational Psychiatry (2017) 7, e1172
Publisher Unknown Creative Commons, Open Access doi:10.1038/tp.2017.135
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538117/pdf/tp2017135a.pdf
| 3 | | R445.00 | |
| | Gabapentin, opioids, and the risk of opioid related death: A population-based nested case control study: | Gabapentin, opioids, and the risk of opioid related death: A population-based nested case control study:
Gabapentin, opioids, and the risk of opioid related death: A population-based nested case control study:
Gabapentin, opioids, and the risk of opioid related death: A population-based nested case control study:
Overview
Prescription opioid use is highly associated with risk of opioid-related death, with 1 of every 550 chronic opioid users dying within approximately 2.5 years of their first opioid prescription. Although gabapentin is widely perceived as safe, drug-induced respiratory depression has been described when gabapentin is used alone or in combination with other medications.
However, no published studies have examined whether concomitant gabapentin therapy is associated with an increased risk of accidental opioid related death in patients receiving opioids. The objective of this study was to investigate whether co-prescription of opioids and gabapentin is associated with an increased risk of accidental opioid-related mortality. We conducted a population-based nested case-control study among opioid users who were residents of Ontario, Canada.
In this study we found that among patients receiving prescription opioids, concomitant treatment with gabapentin was associated with a substantial increase in the risk of opioid-related death. Clinicians should consider carefully whether to continue prescribing this combination of products and, when the combination is deemed necessary, should closely monitor their patients and adjust opioid dose accordingly. Future research should investigate whether a similar interaction exists between pregabalin and opioids.
Acknowledgement
Author Tara Gomes, David N. Juurlink, Tony Antoniou, Muhammad M. Mamdani, J. Michael Paterson and Wim van den Brink.
Journal PLoS Medicine Volume 14 Issue 10
Publisher Cross Mark URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626029/pdf/pmed.1002396.pdf
| 3 | | R470.00 | |
| | Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase. | Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase.
Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase.
Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase.
Overview
Mitochondrial DNA (mtDNA), the discrete genome which encodes subunits of the mitochondrial respiratory chain, is present at highly variable copy numbers across cell types. Though severe mtDNA depletion dramatically reduces mitochondrial function, the impact of tissue-specific mtDNA reduction remains debated. Previously, our lab identified reduced mtDNA quantity in the putamen of Parkinson's Disease (PD) patients who had developed L-DOPA Induced Dyskinesia (LID), compared to PD patients who had not developed LID and healthy subjects.
Here, we present the consequences of mtDNA depletion by ethidium bromide (EtBr) treatment on the bioenergetic function of primary cultured neurons, astrocytes and neuron-enriched cocultures from rat striatum. EtBr also increases glycolytic activity in astrocytes, whereas in neurons it reduces the expression of mitochondrial creatine kinase mRNA and levels of phosphor-creatine. Further, we show that mitochondrial creatine kinase mRNA is similarly downregulated in dyskinetic PD patients, compared to both non-dyskinetic PD patients and healthy subjects.
Our data support a hypothesis that reduced striatal mtDNA contributes to energetic dysregulation in the dyskinetic striatum by destabilizing the energy buffering system of the phospho-creatine/creatine shuttle.
Acknowledgement
Author Emily Booth Warren, Aidan Edward Aicher, Joshua Patrick Fessel and Christine Konradi
Journal PLoS ONE
Publisher Cross Mark
| 3 | | R455.00 | |
| | Pediatric multiple sclerosis: current perspectives on health behaviours | Pediatric multiple sclerosis: current perspectives on health behaviours
Pediatric multiple sclerosis: current perspectives on health behaviours
Pediatric multiple sclerosis: current perspectives on health behaviours
Overview
Pediatric-onset multiple sclerosis (POMS) accounts for -5% of all multiple sclerosis cases, and has a prevalence of -10,000 children in the USA. POMS is associated with a higher relapse rate, and results in irreversible disability on average 10 years earlier than adult-onset multiple sclerosis. Other manifestations of POMS include mental and physical fatigue, cognitive impairment, and depression. Health behaviours of physical activity, diet, and sleep may have potential benefits in POMS, and present a scoping review of the existing literature.
Physical activity participation was associated with reduced relapse rate, disease burden, and sleep/rest fatigue symptoms. Nutritional factors, particularly vitamin D intake, may be associated with relapse rate. Obesity has been associated with increased risk of developing POMS. POMS is associated with better sleep hygiene, and this may benefit fatigue and quality of life.
Participation in health behaviours, particularly physical activity, diet, and sleep, may have benefits for POMS. Nevertheless, there are currently no interventions targeting promotion of these behaviours and examining the benefits of managing the primary and secondary manifestations of POMS.
Acknowledgement
Author Elizabeth Morghen Sikes, Robert W Motl , Jayne M Ness
Journal Pediatric Health, Medicine and Therapeutics 2018:9 17–25
Publisher Dovepress
| 3 | | R450.00 | |
| | Non-invasive Brain Stimulation in Children with Unilateral Cerebral Palsy: a protocol and risk mitigation guide | Non-invasive Brain Stimulation in Children with Unilateral Cerebral Palsy: a protocol and risk mitigation guide
Non-invasive Brain Stimulation in Children with Unilateral Cerebral Palsy: a protocol and risk mitigation guide
Non-invasive Brain Stimulation in Children with Unilateral Cerebral Palsy: a protocol and risk mitigation guide Overview
Non-invasive brain stimulation has been increasingly investigated, mainly in adults, with the aims of influencing motor recovery after stroke. However, a consensus on safety and optimal study design has not been established in pediatrics. The low incidence of reported major adverse events in adults with and without clinical conditions has expedited the exploration of NIBS in children with paralleled purposes to influence motor skill development after neurological injury. Considering developmental variability in children, with or without a neurologic diagnosis, adult dosing and protocols may not be appropriate.
Combining our experiences has allowed us to improve our own protocols, with the immediate goal of child safety and the overarching goal to establish a consensus that helps to define best NIBS practice and practice guidelines
The purpose of this paper is to present recommendations and tools for the prevention and mitigation of adverse events (AEs) during NIBS in children with unilateral cerebral palsy (UCP). Consistent reporting of safety, feasibility, and tolerability will refine NIBS practice guidelines contributing to future clinical translations of NIBS.
Acknowledgement
Author Bernadette T. Gillick, Andrew M. Gordon, Tim Feyma , Linda E. Krach, Jason Carmel, Tonya L. Rich, Yannick Bleyenheuft and Kathleen Friel
Journal Frontiers in Pediatrics Volume 6 Article 56
Publisher Cross Mark https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864860/pdf/fped-06-00056.pdf
| 3 | | R455.00 | |
| | Transition Needs of Adolescents With Sickle Cell Disease. | Transition Needs of Adolescents With Sickle Cell Disease.
Transition Needs of Adolescents With Sickle Cell Disease.
Transition Needs of Adolescents With Sickle Cell Disease.
Overview
This article describes how adolescents with sickle cell disease (SCD) perceive their ability to perform everyday tasks required for transition to adult health care and independent living. SCD negatively affects transition from pediatric to adult health care and independent living (Anie & Telfair, 2005).
The Adolescent Autonomy Checklist (AAC) was adapted to include skills associated with managing SCD (AAC-SCD) and was administered to adolescents during clinic visits. Participants indicated "can do already" or "needs practice" for 100 activities in 12 categories. Of 122 patients, the percentage of adolescents who needed practice was greatest in living arrangements (38.7%), money management (35.8%), vocational skills (29.6%), and health care skills (25.5%).
We found a significant effect of age and of cerebrovascular injury on the percentage of those who reported "needs practice" in multiple categories. We found no effect of gender and limited effect of haemoglobin phenotype on any skill category. Findings support the need for educational intervention to improve transition skills in adolescents with SCD.
Acknowledgement:
Author: Abel RA, Cho E, Chadwick-Mansker KR, D'Souza N, Housten AJ, King AA
Journal:
The American Journal of Occupational Therapy Volume 69 Issue 2
Publisher: AOTA Press
| 3 | | R455.00 | |
| | Dose and Timing in Neurorehabilitation: Prescribing Motor Therapy After Stroke | Dose and Timing in Neurorehabilitation: Prescribing Motor Therapy After Stroke
Dose and Timing in Neurorehabilitation: Prescribing Motor Therapy After Stroke
Dose and Timing in Neuro-rehabilitation: Prescribing Motor Therapy After Stroke.
Overview
Prescribing the most appropriate dose of motor therapy for individual patients is a challenge because minimal data are available and a large number of factors are unknown. This review explores the concept of dose and reviews the most recent findings in the field of neuro-rehabilitation, with a focus on relearning motor skills after stroke.
Appropriate dosing involves the prescription of a specific amount of an active ingredient, at a specific frequency and duration. Dosing parameters, particularly amount, are not well defined or quantified in most studies. Compiling data across studies indicates a positive, moderate dose-response relationship, indicating that more movement practice results in better outcomes. This relationship is confounded by time after stroke.
These findings suggest that substantially more movement practice may be necessary to achieve better outcomes for people living with the disabling consequences of stroke. Preclinical investigations are needed to elucidate many of the unknowns and allow for a more biologically driven rehabilitation prescription process. Likewise, clinical investigations are needed to determine the dose-response relationships and examine the potential dose-timing interaction in humans.
Acknowledgement:
Author: Lang CE, Lohse KR, Birkenmeier RL
Journal: Current Opinion in Neurology.
Publisher: HHS Public Access
| 3 | | R430.00 | |
| | Is the Serum Oxytocin Level Altered by Treatment in Rheumatoid Arthritis Patients Complicated with Depression | Is the Serum Oxytocin Level Altered by Treatment in Rheumatoid Arthritis Patients Complicated with Depression
Is the Serum Oxytocin Level Altered by Treatment in Rheumatoid Arthritis Patients Complicated with Depression
Is the Serum Oxytocin Level Altered By Treatment In Rheumatoid Arthritis Patients Complicated With Depression?
Overview
The objective of this study was to investigate the factors associated with depression, including serum oxytocin levels, disease activity, activities of daily living, and quality of life, and their effects on rheumatoid arthritis.
This study included 42 RA patients who received treatment with a biological agent. We measured the following variables before and after 6 months of treatment: baseline characteristics, including age, sex, disease duration, smoking, and body mass index; prednisolone and methotrexate dose; serum level of matrix metalloproteinase -3; erythrocyte sedimentation rate; and C-reactive protein level.
The HAM-D score significantly correlated with the SDAI, and the mental component summary score of SF-36. However, the serum OXT levels did not correlate with the HAM-D score. Regression analysis using the HAM-D score as the objective variable identified female sex, smoking, BMI, and all the three component scores of SF-36, but not serum OXT levels, as significant factors. The variables of female sex, smoking, BMI, and QOL correlated with depression complicated with RA. However, serum OXT levels did not correlate directly.
Acknowledgement Author Yusuke Miwa , Hidekazu Furuya, Ryo Yanai, Tsuyoshi Kasama, and Kenji Sanada
Journal European Journal of Rheumatology ( EJR) 2018; 5: 22-6
Publisher Medical Research and Education Association
| 3 | | R430.00 | |
| | Head and Neck Reconstruction with Pedicled Flaps in the Free Flap Area | Head and Neck Reconstruction with Pedicled Flaps in the Free Flap Area
Head and Neck Reconstruction with Pedicled Flaps in the Free Flap Area
Head and Neck Reconstruction with Pedicled Flaps in the Free Flap Era.
Overview
Nowadays, the transposition of micro-vascular free flaps is the most popular method for management of head and neck defects. However, not all patients are suitable candidates for free flap reconstruction. In addition, not every defect requires a free flap transfer to achieve good functional results. The aim of this study was to assess whether pedicled flap reconstruction of head and neck defects is inferior to micro-vascular free flap reconstruction in terms of complications, functionality and prognosis.
A total of 93 patients, the majority with oral cancer, were included, of which 64 were pedicled flap reconstructions (69%). The results showed no significant differences in terms of functional outcome, flap necrosis and complications in each type of reconstruction.
Multivariate regression analysis of complicated flap healing showed that only co-morbidities remained an explaining factor. Survival analysis and proportional hazard regression analysis regarding cancer relapse or distant metastasis, showed no significant differences in prognosis of patients concerning both types of reconstruction. Pedicled flaps were not significantly inferior to free flaps for reconstruction of head and neck defects, considering functionality, complications and prognosis.
Acknowledgement
Author:
R. MAHIEU, G. COLLETTI, P. BONOMO, G. PARRINELLO, A. IAVARONE, G. DOLIVET, L. LIVI, A. DEGANELLO
Journal:
Acta Otorhinolaryngol Ital 2016;36:459-468
Publisher:
Azienda Ospedaliero-Universitaria Careggi
| 3 | | R450.00 | |
| | Sensitivity and specificity of CT scan in revealing skull fracture in medico-legal head injury victims. | Sensitivity and specificity of CT scan in revealing skull fracture in medico-legal head injury victims.
Sensitivity and specificity of CT scan in revealing skull fracture in medico-legal head injury victims.
Overview:
Aims: The study was conducted with the objective of knowing the sensitivity and specificity of ante-mortem CT scan findings indicating the presence or absence of skull fractures.
Methods: Findings were confirmed during post-mortem examination of the subjects who had died during management but who had not had any surgical intervention. A comparative study of ante-mortem CT scan and autopsy findings with respect to fracture in traumatic head injuries was undertaken on 60 deceased individuals brought in for medico-legal post-mortem examination over a period of two years.
Results: Considering the autopsy findings as the gold standard, we have concluded that 14.6 per cent of the fractures were missed on CT scan findings compared to fractures found during autopsy. The sensitivity of CT scan for skull fractures was found to be 85.4 per cent and specificity was 100 per cent. Kappa was 0.787, which shows good agreement with p<0.001, which was highly significant.
Conclusion: In developing countries, images are interpreted in the axial plane only on a CT scan of the head, which may be due to a lack of financial and human resources. For better delineation of fractures, the use of techniques like multi-detector CT with sagittal and coronal reformations should be considered in the routine interpretation of a CT scan of the head.
Acknowledgement
Author:
Chawla H, Yadav RK, Griwan MS, Malhotra R, Paliwal PK
Journal:
The Australasian medical journal.
Publisher:
The Australasian medical journal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531150/pdf/AMJ-08-235.pdf
| 3 | | R385.00 | |
| | Standard of care and guidelines in prevention and diagnosis of venous thromboembolism: medico-legal implications. | Standard of care and guidelines in prevention and diagnosis of venous thromboembolism: medico-legal implications.
Standard of care and guidelines in prevention and diagnosis of venous thromboembolism: medico-legal implications.
Overview
Concerning recent Italian laws and jurisprudential statements, guidelines application involves several difficulties in clinical practice, regarding prevention, diagnosis and therapy of venous thromboembolism. International scientific community systematically developed statements about this disease in order to optimize the available resources in prophylaxis, diagnosis and therapy. Incongruous prevention, missed or delayed diagnosis and/or inadequate treatment of this disease can frequently give rise to medico-legal litigation.
Acknowledgement
Author:
Vassalini M, Verzeletti A, De Ferrari F
Journal:
Monaldi archives for chest disease
Publisher:
PIME Editrice
http://www.monaldi-archives.org/index.php/macd/article/view/25/728
| 3 | | R430.00 | |
| | Medical Tourism. | Medical Tourism.
Overview
BACKGROUND: Medical tourism is a burgeoning industry in our region. It involves patients travelling outside of their home country for medical treatment.
OBJECTIVE:
This article provides an outline of the current research around medical tourism, especially its impact on Australians.
DISCUSSION:
Patients are increasingly seeking a variety of medical treatments abroad, particularly those involving cosmetic surgery and dental treatment, often in countries in South-East Asia. Adverse events may occur during medical treatment abroad, which raises medico-legal and insurance issues, as well as concerns regarding follow-up of patients. General practitioners need to be prepared to offer advice, including travel health advice, to patients seeking medical treatment abroad
Acknowledgement
Author:
Leggat P
Journal:
Australian family physician.
Publisher:
Focus Environmental
| 3 | | R360.00 | |
| | There are things that we know that we know, and there are things that we do not know we do not know: Confidence in decision-making. | There are things that we know that we know, and there are things that we do not know we do not know: Confidence in decision-making.
There are things that we know that we know, and there are things that we do not know we do not know: Confidence in decision-making.
Overview
Metacognition, the ability to think about our own thoughts, is a fundamental component of our mental life and is involved in memory, learning, planning and decision-making. Here we focus on one aspect of metacognition, namely confidence in perceptual decisions. We review the literature in psychophysics, neuropsychology and neuroscience. Although still a very new field, several recent studies suggest there are specific brain circuits devoted to monitoring and reporting confidence, whereas others suggest that confidence information is encoded within decision-making circuits. We provide suggestions, based on interdisciplinary research, to disentangle these disparate results.
Acknowledgement
Author:
Grimaldi P, Lau H, Basso MA
Journal:
Neuroscience and biobehavioral reviews.
Publisher:
Department of Health and Human Services.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501881/pdf/nihms-692179.pdf
| 3 | | R420.00 | |
| | Evaluating intervention using time aids in children with disabilities. | Evaluating intervention using time aids in children with disabilities.
Evaluating intervention using time aids in children with disabilities.
OVERVIEW
Nowadays, children with difficulties in managing time in everyday life are at risk of delayed development of time-processing skills compared with their same-aged peers. Thus, Children with autism spectrum disorders (ASD) and children with attention deficit hyperactivity disorder (ADHD) have been reported to exhibit problems in time perception/time sense as compared with typically developing children.
The objective of this study was to evaluate complex intervention using time aids for children with intellectual and developmental disabilities who exhibit limitations in daily time management. The participants of this study were children aged between 6-11 who were suffering from conditions such as ADHD, autism spectrum disorders, mild or moderate intellectual disability, spina bifida, and cerebral palsy. This study equally used a Randomized Block and Waiting List control group design, with 25 children allocated to control and 22 to intervention group.
Results from this study indicated that Children in both groups gained significantly in time-processing ability between the first and second data collection, meanwhile the children in the intervention group improved time-processing ability significantly more than controls.
ACKNOWLEDGEMENT
AUTHORS: Gunnel Janeslätt, Anders Kottorp & Mats Granlund
JOURNAL: Scandinavian Journal of Occupational Therapy
PUBLISHER: Taylor and Francis online
URL: http://www.tandfonline.com
| 3 | | R450.00 | |
| | Exploring the Nature of the Intention, Meaning and Perception Process of the Neuro-occupation Model to Understand Adaptation to Change. | Exploring the Nature of the Intention, Meaning and Perception Process of the Neuro-occupation Model to Understand Adaptation to Change.
Exploring the Nature of the Intention, Meaning and Perception Process of the Neuro-occupation Model to Understand Adaptation to Change.
OVERVIEW
The human condition is completely individualized and unpredictable since change does not follow a linear path. However, the theoretical model of neuro-occupation, intention, meaning and perception, sought to describe the symbiotic relationship between occupation and the brain, as a chaotic, self-organized, complex system. It is apparent that lack of evidence has also limited its applicability to practice.
The aim of this study was to track the postulates of the model within the daily experiences of subjects. Thus, a qualitative multiple case- study design, typically used for testing models was used for content analysis. During the study, an underpinning principle of the model, defined a circular causality feedback process, which was confirmed as described through tracing the repetitive processes within the lived experience of two Iranian men.
The results from this study however suggested that continual adaptation occurred in lives interrupted by cerebrovascular accident, which enabled the subjects to return to expression of meaning through purposeful occupation and continually re-shaped their perceptions.
ACKNOWLEDGEMENT
AUTHORS: Seyed Alireza Derakhshanrad, Emily Piven, Seyed Ali Hosseini Farahnaz Mohammadi Shahboulaghi, Homer Nazeran & Mehdi Rassafiani
JOURNAL: Occupational Therapy International
PUBLISHER: John Willey & Sons Limited
URL: http://www.wileyonlinelibrary.com
| 3 | | R325.00 | |
| | Interventions aimed at improving the ability to use everyday technology in work after brain injury. | Interventions aimed at improving the ability to use everyday technology in work after brain injury.
Interventions aimed at improving the ability to use everyday technology in work after brain injury.
Abstract:
Objective: The aim of this study was to explore and describe how client-centred occupational therapy interventions may support and improve the ability to use everyday technology (ET) in work tasks in people with acquired brain injury (ABI).
Method: A qualitative, descriptive multiple-case study was designed, and occupation-based interventions were provided to three working-age participants with ABI. Multiple sources were used to collect data throughout the three intervention processes, including assessments, field notes, and interviews. The Canadian Occupational Performance Measure and the Management of Everyday Technology Assessment were administered before the interventions, after the interventions and at a follow-up session 2–3 months subsequent to the interventions.
Results: The three intervention processes initially consisted of similar actions, but subsequently the actions took on a different focus and intensity for each case. All of the goals in each of the three case processes were achieved, and both perceived and observed abilities to use ET in work tasks improved.
Conclusions: Client-centred occupational therapy interventions might have the potential to improve the ability to use ET in work tasks in people with ABI. OVERVIEW
There is currently an increased use of everyday technology (ET), such as coffee machines, mobile phones, and computers because of the development of an information society.
The aim of this study was to explore and describe how client-centred occupational therapy interventions may support and improve the ability to use everyday technology (ET) in work tasks in people with acquired brain injury (ABI). During this research, a qualitative, descriptive multiple-case study was designed, and occupation-based interventions were provided to three working-age participants with ABI. Multiple sources including assessments, field notes, and interviews were used to collect data throughout the three intervention processes. It is worth men toning that The Canadian Occupational Performance Measure and the Management of Everyday Technology Assessment were administered both before and after the interventions as well as at a follow-up session 2–3 months after the interventions.
The results of this study revealed that the three intervention processes initially consisted of similar actions, but subsequently the actions took on a different focus and intensity for each case. It was therefore concluded that client-centred occupational therapy interventions might have the potential to improve the ability to use ET in work tasks in people with ABI.
ACKNOWLEDGEMENT
AUTHORS: Ann-Charlotte Kassberg, Maria Prellwitz, Camilla Malinowsky & Maria Larsson-Lund
JOURNAL: Scandinavian Journal of Occupational Therapy
PUBLISHER: Taylor and Francis
URL: http://taylorandfrancis.com
| 3 | | R435.00 | |
| | Magnetic resonance imaging and positron emission tomography in the diagnosis of neurodegenerative dementias. | Magnetic resonance imaging and positron emission tomography in the diagnosis of neurodegenerative dementias.
Magnetic resonance imaging and positron emission tomography in the diagnosis of neurodegenerative dementias.
OVERVIEW
There are evidences that more than one-third of Ameri¬can households report failing to access needed den¬tal care in each year because of cost. Thus, den¬tal problems are an increasing cause of emergency room visits.
The aim of this study was to explore low-income parents’ perceptions of oral health and of mid-level dental providers as a means of improving access to care. Of course, as states increasingly consider adding mid-level providers to the dental workforce, it is imperative to understand the views of potential patients toward such providers since the success of any strategy depends, in part, upon the willingness of potential patients to be treated by them. The qualitative research methodology was used for this study and in-depth interviews were conducted with 20 low-income parents to assess their perceptions of oral health, access to and need for dental care, and potential acceptance of mid-level dental providers. Interview transcripts were analysed by a team of researchers using interpretive research methods.
The results from this study suggested that the respondents had a strong desire to maintain their families’ oral health, as well as their perception that they face signifi¬cant barriers to receiving needed care.
ACKNOWLEDGEMENT
AUTHORS: Nicoll KL, Phillips E, Shaefer HL, Simoncic T.
JOURNAL: Functional Neurology
PUBLISHER: Nova Science Publisher
URL: https://www.novapublishers.com | 3 | | R475.00 | |
| | Performance or activities of daily living among hospitalised cancer patients. | Performance or activities of daily living among hospitalised cancer patients.
Performance or activities of daily living among hospitalised cancer patients.
OVERVIEW
It has been revealed that digital radiography encompasses both computed It is evident that problems with performance of activities of daily living (ADL) tasks have an impact on patients’ quality of life as well as their ability to stay independent. Many researches have nonetheless documented that rehabilitation is needed when cancer patients experience decreased ability to perform ADL.
Although rehabilitation may include activities of daily living (ADL) tasks, very little is still known about how cancer patients perform these tasks and how they prioritize their daily activities. The objective of this study was therefore to identify and characterize ADL task performance problems among a group of adult disabled hospitalized cancer patients using interview and questionnaire. This Cross-sectional study on prevalence of ADL task performance problems experienced by disabled hospitalized cancer patients was carried out using the Activities of Daily Living Questionnaire and the Canadian Occupational Performance Measure.
The results of this study indicated that all 118 patients reported problems with ADL task performance.
ACKNOWLEDGEMENT
AUTHOR: Line Lindhal-Jacobsen, Dorte Gilsa Hansen, Eva Ejlersen Waehrens, Karen La Cour & Jens Sondergaard
JOURNAL: Scandinavian Journal of Occupational Therapy
PUBLISHER: Taylor and Francis Online
URL: http://www.tandfonline.com
| 3 | | R475.00 | |
| | Placebo effects in trials evaluating 12 selected minimally invasive interventions: a systematic review and meta-analysis. | Placebo effects in trials evaluating 12 selected minimally invasive interventions: a systematic review and meta-analysis.
Placebo effects in trials evaluating 12 selected minimally invasive interventions: a systematic review and meta-analysis.
OVERVIEW
The objective of this study was to analyse the impact of placebo effects on outcome in trials of selected minimally invasive procedures and to assess reported adverse events in both trial arms. The design for this study was nonetheless a systematic review and meta-analysis.
The data for this study was selected by searching MEDLINE and Cochrane library so as to identify systematic reviews of musculoskeletal, neurological and cardiac conditions that were published between January 2009 and January 2014 comparing selected minimally invasive with placebo (sham) procedures. During this research, effect sizes (ES) in the active and placebo arms in the trials’ primary and pooled secondary end points were calculated. The association between end points in the active and sham groups were nevertheless analysed using the linear regression.
This study was however concluded that the generally small differences in ES between active treatment and sham suggest that nonspecific mechanisms, including placebo, are major predictors of the observed effects
ACKNOWLEDGEMENT
AUTHOR: Robin Holtedahl, Jens Ivar Brox, Ole Tjomsland
JOURNAL: Stroke and Vascular Neurology
PUBLISHER: BMJ Open
URL: http://bmjopen.bmj.com/ | 3 | | R375.00 | |
| | Postextubation Dysphagia in Critical Patients: A First Report from the Largest Step-Down Intensive Care Unit in Greece. | Postextubation Dysphagia in Critical Patients: A First Report from the Largest Step-Down Intensive Care Unit in Greece.
Postextubation Dysphagia in Critical Patients: A First Report from the Largest Step-Down Intensive Care Unit in Greece.
OVERVIEW
Oropharyngeal dysphagia or swallowing disorders refers to difficulty receiving, maintaining, and transferring food and liquids from the mouth to the oesophagus. If this is left untreated, it can result to serious complications such as social isolation, respiratory compromise, aspiration pneumonia, malnutrition, and death.
The purpose of this study was to provide preliminary data on the occurrence and impact of postextubation dysphagia in the largest Greek step-down intensive care unit (ICU) over 2 years. This research was however a retrospective observational cohort study of patients referred for swallowing assessment postextubation that was conducted from November 2011, to August 2013. Results from this study indicated that of the 357 patients admitted to the unit during this period, 87, aged 55.8 ± 18.1 years (61 male, 26 female), were referred and evaluated. Of these, 2.3% were found to have no dysphagia, and 21.8% and 75.9% were diagnosed with mild and moderate/severe dysphagia, respectively.
The results of this study suggested the importance of early dysphagia management in critical patients in Greece and globally.
ACKNOWLEDGEMENT
AUTHOR: Georgia A. Malandraki, Vasiliki Markaki, Voula C. Georgopoulos, Loukia Psychogios, and Serafim Nanas
JOURNAL: American Journal of Speech-Language Pathology
PUBLISHER: ASHA
URL: http://www.asha.org | 3 | | R385.00 | |
| | Prognostic Factors for Disability and Sick Leave Patients with Subacute Non-Malignant Pain. | Prognostic Factors for Disability and Sick Leave Patients with Subacute Non-Malignant Pain.
Prognostic Factors for Disability and Sick Leave Patients with Subacute Non-Malignant Pain.
OVERVIEW
Pain is one of the most common reasons patients consult general practice. It has been observed that long-term disability and sick leave due to a pain conditions are associated with huge negative consequences for the individual and for society.
The objective of this systematic review was therefore to identify generic prognostic factors for disability and sick leave in sub-acute pain patients. The setting of this study was nevertheless general practice and other primary care facilities. Participants in this study were adults (>18 years) with a sub-acute non-malignant pain condition. 19 studies were included, referring to a total of 6266 patients suffering from pain in the head, neck, back and shoulders. The primary outcome of this study was long-term disability (>3 months) due to a pain condition whereas the secondary outcome was sick leave, defined as ‘absence from work’ or ‘return-to-work. Data was obtained through a search via PubMed, EMBASE, CINAHL and PEDro databases from 16 from January 2003 to 16 January 2014.
The study was concluded that multiple site pain, high pain severity, older age, baseline disability and longer pain duration were potential prognostic factors for disability across pain sites.
ACKNOWLEDGEMENT
AUTHOR: Gitte H Valentin, Marc S Pilegaard, Henrik B Vaegter, Marianne Rosendal, Lisbeth Ørtenblad, Ulla Væggemose, Robin Christensen
JOURNAL: BMJ General Practice
PUBLISHER: BMJ Open
URL: http://bmjopen.bmj.com
| 3 | | R365.00 | |
| | Relationship between Quantified Instrumental Swallowing Examination and Comprehensive Clinical Swallowing Examination. | Relationship between Quantified Instrumental Swallowing Examination and Comprehensive Clinical Swallowing Examination.
Relationship between Quantified Instrumental Swallowing Examination and Comprehensive Clinical Swallowing Examination.
OVERVIEW
Clinical swallowing examination (CSE) is used in evaluating whether a subject has dysphagia. However, it also includes various clinical methods such as recording the history of the subject’s swallowing difficulty; observing the anatomical structures of the oral cavity, pharynx and larynx; testing sensory and motor functions, behaviour, level of consciousness and speech language ability; and performing a swallowing trial.
Nevertheless, the objective of this study was to identify the correlation between the Mann Assessment of Swallowing Ability (MASA) and the Videofluoroscopic Dysphagia Scale (VDS) to investigate the applicability of the MASA as a follow-up test of swallowing function. Criterion validity was assessed for MASA results versus VDS scores of tests administered to 54 patients who had a stroke and dysphagia. The results of this study indicated that there was a significant correlation between the MASA and the VDS (correlation coefficient =_0.509).
The results from this study further indicated that the MASA holds adequate clinical test–re-test and inter-rater reliabilities and criterion validity for measuring the swallowing abilities of Korean patients who had a stroke and dysphagia.
ACKNOWLEDGEMENT
AUTHORS: Jong-Chi Oh, Ji-Hyuk Park, Min-Ye Jung, Eun-Young Yoo, Ki-Yeon Chang & Teak-Young Lee
JOURNAL: Occupational Therapy International
PUBLISHER: Wiley
URL: http://onlinelibrary.wiley.com | 3 | | R355.00 | |
| | Rewarding yet demanding: client perspectives on enabling occupations during early stages of recovery from Schizophrenia. | Rewarding yet demanding: client perspectives on enabling occupations during early stages of recovery from Schizophrenia.
Rewarding yet demanding: client perspectives on enabling occupations during early stages of recovery from Schizophrenia.
OVERVIEW
Schizophrenia is known to be a severe mental illness that is characterized by psychotic symptoms, negative symptoms such as apathy and anhedonia, as well as impaired cognitive functioning. Schizophrenia can also result to significant risk of impaired functioning in areas such as self-care, independent living skills, social relationships, work, and going to school.
The aim of this study was therefore to seek a better understanding of how people with schizophrenia experience an occupational therapy intervention designed to enable them to carry out meaningful occupations in the early phases of recovery. The methodology of this research was a qualitative design that comprised of an eight-week client-centred occupational therapy intervention with semi-structured interviews of five of the six clients out of 10 who completed the intervention. It is imperative to acknowledge that Braun and Clark’s thematic analysis was applied to the transcripts.
Results from this study indicated that participants valued engaging in real-life occupations while anchoring new strategies.
ACKNOWLEDGEMENT
AUTHORS: S.T.B. Bjørkedal, A.M.B. Torsting and T. Møller
JOURNAL: Scandinavian Journal of Occupational Therapy
PUBLISHER: Taylor and Francis
URL: http://www.tandfonline.com | 3 | | R360.00 | |
| | The potential role of neuropathic mechanisms in dry eye syndromes. | The potential role of neuropathic mechanisms in dry eye syndromes.
The potential role of neuropathic mechanisms in dry eye syndromes.
OVERVIEW
According to the 2007 International Dry Eye Workshop, dry eye syndromes (DES) are multifactorial diseases of the tears, lids and ocular surface which can result in symptoms of discomfort and/or visual disturbance and/or tear film instability with the potential for damage to the ocular surface.
This disease is often accompanied by Meibomian gland dysfunction, increased osmolarity of the tear film and inflammation of the ocular surface1 and may be exacerbated by infrequent and/or incomplete blinking. Dry eye symptoms could either be nociceptive and neuropathic symptoms. The aim of this review was to discuss the potential for ocular symptoms involving neuropathic mechanisms to contribute to psychosocial problems such as depression, stress, anxiety and sleep disorders as well as for these types of psychosocial problems to contribute to neuropathic mechanisms and dry eye syndromes.
This is study is relevant because failure to consider the possibility that neuropathic mechanisms can contribute to dry eye syndromes may reduce accuracy of diagnosis and the suitability of treatment provided.
ACKNOWLEDGEMENT
AUTHORS: Charles W. Mcmonnies
JOURNAL: Journal of Optometry
PUBLISHER: Elsevier Inc
URL: http://elsevier.com
| 3 | | R430.00 | |
| | What Drives Quality Improvement in Chronic Kidney Disease in Primary Care. | What Drives Quality Improvement in Chronic Kidney Disease in Primary Care.
What Drives Quality Improvement in Chronic Kidney Disease in Primary Care.
OVERVIEW
Chronic kidney disease (CKD) is increasingly becoming a public health issue because it’s very common. More so, CKD is an established, independent risk factor for cardiovascular disease and there are indications that a significant number of patients with CKD die from cardiovascular complications than progress to end-stage kidney disease.
This study was process of evaluating the Quality Improvement in Chronic Kidney Disease (QICKD) study, comparing audit-based education (ABE) and sending clinical guidelines and prompts (G&P) with usual practice, in improving systolic blood pressure control in primary care. This study however took place in 4 primary care practices in England (2received ABE, and 2 G&P). The participants of this study were focus groups conducted with staff from each of the 4 primary care practices.
Based on results of the study, it was concluded that improving quality in CKD is complex. The results also indicated that lack of awareness of clinical guidelines and scepticism about their validity are barriers to change.
ACKNOWLEDGEMENT
AUTHORS: Akin Nihat, Simon de Lusignan, Nicola Thomas, Mohammad Aumran Tahir, Hugh Gallagher
JOURNAL: General Practice
PUBLISHER: BMJ Open
| 3 | | R365.00 | |